Ceftiofur Regulates LPS-Induced Production of Cytokines and Improves LPS-Induced Survival Rate in Mice

@article{Ci2008CeftiofurRL,
  title={Ceftiofur Regulates LPS-Induced Production of Cytokines and Improves LPS-Induced Survival Rate in Mice},
  author={Xinxin Ci and Hongyu Li and Yu Song and Na An and Qinlei Yu and Fanqin Zeng and Xuming Deng},
  journal={Inflammation},
  year={2008},
  volume={31},
  pages={422-427}
}
The influence of ceftiofur on immune responses has been suggested by results of in vitro studies. This effect was studied using a murine model that measured mortality and early cytokine responses after challenge with endotoxin. To investigate the treatment of endotoxic mice with ceftiofur, mice were pretreated with ceftiofur at different times before and after challenge with a lethal dose of 30 mg/kg lipopolysaccharide (LPS). We found that 20 mg/kg ceftiofur had a significant protective effect… CONTINUE READING
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