Cefpirome and continuous venovenous hemofiltration

Abstract

Sir: The initial dosing of antimicrobial treatment in sepsis should clearly be high enough to achieve blood and tissue levels well above the minimal inhibitory concentration of the target micro-organisms. Obviously, the initial loading dose does not depend on elimination impairment, but rather on the apparent volume of distribution (VD). Gomez et al. [1… (More)
DOI: 10.1007/s001340051266

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