Cefditoren Pivoxil

  title={Cefditoren Pivoxil},
  author={Keri Wellington and Monique P. Curran},
SummaryAbstractCefditoren pivoxil (Spectracef®, Meiact®) is a third-generation oral cephalosporin with a broad spectrum of activity against pathogens, including both Gram-positive and -negative bacteria, and is stable to hydrolysis by many common β-lactamases. Cefditoren pivoxil is approved for use in the treatment of acute exacerbations of chronic bronchitis (AECB), mild-to-moderate community-acquired pneumonia (CAP), acute maxillary sinusitis, acute pharyngitis/tonsillitis and uncomplicated… 
10 Citations
In vitro Activity of Cefditoren against Middle Ear Fluid Isolates from Costa Rican Children with Otitis Media
Evaluation of the in vitro activity of cefditoren against pathogens collected from the MEF of Costa Rican children with OM allows it to be included as one of the best choices among antibiotics that are widely used in empiric therapy for OM in pediatric patients.
Systemic antibiotic therapy of patients with acute bacterial sinusitis taking into account resistance
Data is presented on a new universal cephalosporin of the 3rd generation, as a second- and third-line drug, due to its high activity against most causative agents of acute bacterial rhinosinusitis, and clinical observation using the above antibacterial agent within the framework of the considered topics.
Liver uptake of cefditoren is mediated by OATP1B1 and OATP2B1 in humans and Oatp1a1, Oatp1a4, and Oatp1b2 in rats
It is indicated that OATP1B1 and OatP2B1 are involved in hepatic uptake of cefditoren in humans, and multiple Oatps might participate in this process in rats, which could prompt the up-regulation of Oatp1a1 expression.
Molecular mechanisms of biliary excretion of cefditoren and the effects of cefditoren on the expression levels of hepatic transporters.
Results indicate that Mrp2 and Bcrp may be involved in the biliary excretion of cefditoren, a third generation cephalosporin antibiotics, which can up-regulate the expression levels ofMrp2, BCrp and Oat2, and down-regulates P-gp and Oct1 mRNA expression.
Prodrug study of plinabulin using a click strategy focused on the effects of a replaceable water-solubilizing moiety.
The newly introduced water-solubilizing moiety provided interesting effects on the water solubility and half-life of the prodrugs.
Synthesis, Characterization, Crystal Structure and Biological Study of Carboxamides Obtained from 2-Aminothiazole Derivatives
Two series of novel thiazolylcarboxamide derivatives were synthesized by the reaction of ethyl 2-amino-4-methylthiazole-5-carboxylate or 1-(2-amino-4-methylthiazol-5-yl)ethan-1-one with four
Efficient one-pot synthesis of ethyl 2-substitued-4-methylthiazole-5-carboxylates
A new and practical one-pot procedure for the synthesis of several 2-sustituted-4-methylthiazole-5-carboxylates from commercially available starting materials is described. Under mild reaction


Cefditoren, a New Aminothiazolyl Cephalosporin
Cefditoren pivoxil, an oral third‐generation cephalosporin, was approved by the Food and Drug Administration in September 2001 and has potential for empiric management of most commonly encountered respiratory tract infections.
Cefditoren Pivoxil
Cefditoren pivoxil dosage regimens were as effective as a 10-day course of either cefadroxil 500mg once daily or cefuroxime axetil 250mg twice daily in treating uncomplicated skin and skin structure infections, including those caused by S. aureus and S. pyogenes.
Cefditoren Pivoxil
Cefditoren pivoxil is a third-generation cephalosporin, which has been available in Japan for a number of years and has recently been approved by the Food and Drug Administration in the US for use in
Cefdinir: a review of its use in the management of mild-to-moderate bacterial infections.
Clinical evidence indicates that cefdinir is an effective and generally well tolerated drug with superior taste over comparator antibacterial agents and is therefore a good option for the treatment of adults, adolescents and paediatric patients with specific mild-to-moderate respiratory tract or skin infections, particularly in areas where beta-lactamase-mediated resistance among common community-acquired pathogens is a concern.
An in vitro characterization of cefditoren, a new oral cephalosporin.
Investigation of the effect of laboratory variables on the in vitro activity of cefditoren indicates that it will present no special problems when tested in the clinical setting against bacterial pathogens.
Activity of cefditoren against respiratory pathogens.
Multistep studies of cefditoren, co-amoxiclav and cefprozil did not select for resistant mutants after 50 subcultures, compared with cefuroxime and azithromycin, where resistant mutants were selected in two and nine strains, respectively.