Cefazolin high-inoculum effect in methicillin-susceptible Staphylococcus aureus from South American hospitals.

  title={Cefazolin high-inoculum effect in methicillin-susceptible Staphylococcus aureus from South American hospitals.},
  author={Sandra L Rincon and J. Guadalupe Reyes and Lina Paola Carvajal and Natalia Rojas and Fabi{\'a}n Cort{\'e}s and Diana Panesso and M {\'A}ngeles Guzm{\'a}n and Jeannete Zurita and Javier A Adachi and Barbara E. Murray and Esteban C. Nannini and C{\'e}sar A. Arias},
  journal={The Journal of antimicrobial chemotherapy},
  volume={68 12},
OBJECTIVES Clinical failures with cefazolin have been described in high-inoculum infections caused by methicillin-susceptible Staphylococcus aureus (MSSA) producing type A β-lactamase. We investigated the prevalence of the cefazolin inoculum effect (InE) in MSSA from South American hospitals, since cefazolin is used routinely against MSSA due to concerns about the in vivo efficacy of isoxazolyl penicillins. METHODS MSSA isolates were recovered from bloodstream (n = 296) and osteomyelitis (n… CONTINUE READING
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