CedA is a novel Escherichia coli protein that activates the cell division inhibited by chromosomal DNA over-replication.

@article{Katayama1997CedAIA,
  title={CedA is a novel Escherichia coli protein that activates the cell division inhibited by chromosomal DNA over-replication.},
  author={Tsutomu Katayama and Makoto Takata and Kazuhisa Sekimizu},
  journal={Molecular microbiology},
  year={1997},
  volume={26 4},
  pages={687-97}
}
We isolated and characterized a new gene related to the control of cell division regulation in Escherichia coli. At 30 degrees C, the dnaAcos mutant causes over-replication of the chromosome, and colony formation is inhibited. We found that, at this temperature, the dnaAcos cells form filaments; therefore, septum formation is inhibited. This inhibition was independent of SfiA, an inhibitor of the septum-forming protein, FtsZ. To identify factors involved in this pathway of inhibition, we… CONTINUE READING

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