Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels.


BACKGROUND Cecal ligation and puncture is a widely used experimental model of sepsis. AIM OF THE STUDY The present study was aimed to evaluate the influence of the size of the cecal puncture on mortality, bacteremia, endotoxemia and plasma TNF-alpha levels. MATERIALS AND METHODS Female Sprague-Dawley rats underwent cecal ligation and puncture, divided… (More)


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