Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.

@article{Bansal2006Cdx4DH,
  title={Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.},
  author={Dimple Bansal and Claudia Scholl and Stefan Fr{\"o}hling and Elizabeth McDowell and Benjamin Hoyoung Lee and Konstanze Doehner and Patricia Ernst and Alan J. W. Davidson and George Q. Daley and Leonard I. Zon and Dwight Gary Gilliland and Brian J P Huntly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 45},
  pages={16924-9}
}
HOX genes have emerged as critical effectors of leukemogenesis, but the mechanisms that regulate their expression in leukemia are not well understood. Recent data suggest that the caudal homeobox transcription factors CDX1, CDX2, and CDX4, developmental regulators of HOX gene expression, may contribute to HOX gene dysregulation in leukemia. We report here that CDX4 is expressed normally in early hematopoietic progenitors and is expressed aberrantly in approximately 25% of acute myeloid leukemia… CONTINUE READING
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