Cdx1 and c-Myc Foster the Initiation of Transdifferentiation of the Normal Esophageal Squamous Epithelium toward Barrett's Esophagus

@article{Stairs2008Cdx1AC,
  title={Cdx1 and c-Myc Foster the Initiation of Transdifferentiation of the Normal Esophageal Squamous Epithelium toward Barrett's Esophagus},
  author={Douglas B. Stairs and Hiroshi Nakagawa and Andres J. P. Klein-Szanto and Shukriyyah D. Mitchell and Debra G. Silberg and John W Tobias and John Patrick Lynch and Anil K Rustgi},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={1810 - 1820}
}
BACKGROUND Barrett's esophagus is a premalignant condition whereby the normal stratified squamous esophageal epithelium undergoes a transdifferentiation program resulting in a simple columnar epithelium reminiscent of the small intestine. These changes are typically associated with the stratified squamous epithelium chronically exposed to acid and bile salts as a result of gastroesophageal reflux disease (GERD). Despite this well-defined epidemiologic association between acid reflux and Barrett… CONTINUE READING

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