Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53

@article{Seo2005Cdt1TM,
  title={Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53},
  author={JungHee Seo and Yun Chung and Girdhar G Sharma and Eunpyo Moon and W Richard Burack and Tej K Pandita and Kyunghee Choi},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={8176-8186}
}
The exact duplication of chromosomal DNA during each cell cycle ensures the correct inheritance of genetic material from mother to daughter cells. In eukaryotic cells, DNA replication can occur only when the origin of DNA replication is accurately marked by a group of proteins termed licensing proteins. One such protein is Cdt1, which is recruited first to… CONTINUE READING