Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.

@article{Sugimoto2004Cdt1PB,
  title={Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.},
  author={Nozomi Sugimoto and Yasutoshi Tatsumi and Tatsuya Tsurumi and Akio Matsukage and Tohru Kiyono and Hideo Nishitani and Masatoshi Fujita},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 19},
  pages={19691-7}
}
The current concept regarding cell cycle regulation of DNA replication is that Cdt1, together with origin recognition complex and CDC6 proteins, constitutes the machinery that loads the minichromosome maintenance complex, a candidate replicative helicase, onto chromatin during the G(1) phase. The actions of origin recognition complex and CDC6 are suppressed through phosphorylation by cyclin-dependent kinases (Cdks) after S phase to prohibit rereplication. It has been suggested in metazoan cells… CONTINUE READING
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