Cdt1 and geminin: role during cell cycle progression and DNA damage in higher eukaryotes.

@article{Tada2007Cdt1AG,
  title={Cdt1 and geminin: role during cell cycle progression and DNA damage in higher eukaryotes.},
  author={Shusuke Tada},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2007},
  volume={12},
  pages={1629-41}
}
  • Shusuke Tada
  • Published 2007 in
    Frontiers in bioscience : a journal and virtual…
DNA replication in eukaryotic cells must be strictly regulated to ensure that the entire genome is duplicated only once in each cell cycle. For this purpose, the initiation of DNA replication is controlled by the "licensing" reaction, which is established by the formation of a pre-replicative complex (pre-RC) with the sequential assembly of the origin recognition complex (ORC), Cdc6, Cdt1 and Mcm2-7 onto origin regions. Among these, Cdt1 is likely the most important target for regulating… CONTINUE READING
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Bell : Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex

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