Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7

@article{Andrews2007Cdkn1cI,
  title={Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7},
  author={Stuart C Andrews and Michelle D Wood and Simon J. Tunster and Sheila C. Barton and M. Azim Surani and Rosalind M. John},
  journal={BMC Developmental Biology},
  year={2007},
  volume={7},
  pages={53 - 53}
}
Cdkn1c encodes an embryonic cyclin-dependant kinase inhibitor that acts to negatively regulate cell proliferation and, in some tissues, to actively direct differentiation. This gene, which is an imprinted gene expressed only from the maternal allele, lies within a complex region on mouse distal chromosome 7, called the IC2 domain, which contains several other imprinted genes. Studies on mouse embryos suggest a key role for genomic imprinting in regulating embryonic growth and this has led to… CONTINUE READING

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