Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

@article{Choudhury2007Cdkn1aDI,
  title={Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation},
  author={Aaheli Roy Choudhury and Zhenyu Ju and Meta Wulandari Djojosubroto and Andrea Schienke and Andr{\'e} Lechel and Sonja Schaetzlein and Hong Jiang and Anna Stępczyńska and Chunfang Wang and Jan Buer and Han Woong Lee and Thomas von Zglinicki and Arnold Ganser and Peter Schirmacher and Hiromitsu Nakauchi and Karl Lenhard Rudolph},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={99-105}
}
Telomere shortening limits the proliferative lifespan of human cells by activation of DNA damage pathways, including upregulation of the cell cycle inhibitor p21 (encoded by Cdkn1a, also known as Cip1 and Waf1)) (refs. 1–5). Telomere shortening in response to mutation of the gene encoding telomerase is associated with impaired organ maintenance and shortened lifespan in humans and in mice. The in vivo function of p21 in the context of telomere dysfunction is unknown. Here we show that deletion… CONTINUE READING
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