Cdk5 phosphorylates p53 and regulates its activity

@article{Zhang2002Cdk5PP,
  title={Cdk5 phosphorylates p53 and regulates its activity},
  author={Jianwen Zhang and Pavan Krishnamurthy and Gail V. W. Johnson},
  journal={Journal of Neurochemistry},
  year={2002},
  volume={81}
}
Cyclin dependent kinase 5 (Cdk5) is a proline‐direct protein kinase that is most active in the CNS, and has been implicated as a contributing factor in certain neurodegenerative diseases. Further, there is evidence to suggest that Cdk5 may facilitate the progression of apoptosis. However, the mechanisms involved have not been elucidated. The tumor suppressor protein p53, a transcription factor that is regulated by phosphorylation, increases the expression of genes that control growth arrest or… 
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