Cdk5 Promotes Synaptogenesis by Regulating the Subcellular Distribution of the MAGUK Family Member CASK

@article{Samuels2007Cdk5PS,
  title={Cdk5 Promotes Synaptogenesis by Regulating the Subcellular Distribution of the MAGUK Family Member CASK},
  author={Benjamin Adam Samuels and Y T Hsueh and Tianzhi Shu and Haoya Liang and H I Tseng and Chen-Jei Hong and Susan C. Su and Janet Volker and Rachael Lee Neve and David T. Yue and Li-Huei Tsai},
  journal={Neuron},
  year={2007},
  volume={56},
  pages={823-837}
}
Synaptogenesis is a highly regulated process that underlies formation of neural circuitry. Considerable work has demonstrated the capability of some adhesion molecules, such as SynCAM and Neurexins/Neuroligins, to induce synapse formation in vitro. Furthermore, Cdk5 gain of function results in an increased number of synapses in vivo. To gain a better understanding of how Cdk5 might promote synaptogenesis, we investigated potential crosstalk between Cdk5 and the cascade of events mediated by… CONTINUE READING