Cdk5 Is Involved in BDNF-Stimulated Dendritic Growth in Hippocampal Neurons

@article{Cheung2007Cdk5II,
  title={Cdk5 Is Involved in BDNF-Stimulated Dendritic Growth in Hippocampal Neurons},
  author={Zelda H. Cheung and Wing Hong Chin and Yu Chen and Yu Pong Ng and Nancy Y Ip},
  journal={PLoS Biology},
  year={2007},
  volume={5},
  pages={609 - 642}
}
Neurotrophins are key regulators of neuronal survival and differentiation during development. Activation of their cognate receptors, Trk receptors, a family of receptor tyrosine kinases (RTKs), is pivotal for mediating the downstream functions of neurotrophins. Recent studies reveal that cyclin-dependent kinase 5 (Cdk5), a serine/threonine kinase, may modulate RTK signaling through phosphorylation of the receptor. Given the abundant expression of both Cdk5 and Trk receptors in the nervous… CONTINUE READING
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