Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.

@article{Tomizawa2002Cdk5p35RN,
  title={Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.},
  author={Kazuhito Tomizawa and Jun Ohta and Masayuki Matsushita and Akiyoshi Moriwaki and Sheng-tian Li and Kohji Takei and Hideki Asoh zToshihiro Matsui},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 7},
  pages={2590-7}
}
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase with close structural homology to the mitotic Cdks. The complex of Cdk5 and p35, the neuron-specific regulatory subunit of Cdk5, plays important roles in brain development, such as neuronal migration and neurite outgrowth. Moreover, Cdk5 is thought to be involved in the promotion of neurodegeneration in Alzheimer's disease. Cdk5 is abundant in mature neurons; however, its physiological functions in the adult brain… CONTINUE READING
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Distinct cellular compartment of cyclin - dependent kinase 5 ( Cdk 5 ) and neuron - specific Cdk 5 activator protein ( p 35 nck 5 a ) in the developing rat cerebellum

  • M Matsushita, K Tomizawa, +6 authors H Matsui
  • Brain Res
  • 1996
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