Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.

@article{Sundaram2012Cdk5p25inducedCP,
  title={Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.},
  author={Jeyapriya Raja Sundaram and Elizabeth S. Chan and Charlene Priscilla Poore and Tej Kumar Pareek and Wei Fun Cheong and Guanghou Shui and Ning Tang and C Low and Markus R. Wenk and Sashi Kesavapany},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 3},
  pages={1020-34}
}
The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 has been shown to contribute to the pathogenesis in a number of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD). In particular, p25/Cdk5 has been shown to produce hyperphosphorylated tau, neurofibrillary tangles as well as aberrant amyloid precursor protein processing found in AD. Neuroinflammation has been observed alongside the pathogenic process in these… CONTINUE READING

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