Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis.

  title={Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis.},
  author={Dipankar Ray and Yasuhisa Terao and Konstantin T Christov and Philipp Kaldis and Hiroaki Kiyokawa},
  volume={13 5},
The concept of targeting G(1) cyclin-dependent kinases (CDKs) in breast cancer treatments is supported by the fact that the genetic ablation of Cdk4 had minimal impacts on normal cell proliferation in majority of cell types, resulting in near-normal mouse development, whereas such loss of Cdk4 completely abrogated ErbB-2/neu-induced mammary tumorigenesis in mice. In most human breast cancer tissues, another G(1)-regulatory CDK, CDK2, is also hyperactivated by various mechanisms and is believed… CONTINUE READING