Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT

  title={Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT},
  author={Kristopher J. Stanya and Yu Cun Liu and Anthony R. Means and Hung-Ying Kao},
  journal={The Journal of Cell Biology},
  pages={49 - 61}
Silencing mediator for retinoic acid and thyroid hormone receptor (SMRT) is a transcriptional corepressor that participates in diverse signaling pathways and human diseases. However, regulation of SMRT stability remains largely unexplored. We show that the peptidyl-prolyl isomerase Pin1 interacts with SMRT both in vitro and in mammalian cells. This interaction requires the WW domain of Pin1 and SMRT phosphorylation. Pin1 regulates SMRT protein stability, thereby affecting SMRT-dependent… CONTINUE READING
29 Citations
56 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 29 extracted citations


Publications referenced by this paper.
Showing 1-10 of 56 references

PIN 1 , the cell cycle and cancer

  • E. Yeh, M. Cunningham, +7 authors T. Uchida
  • Nat . Rev . Cancer .
  • 2007

The co - repressor silencing mediator for retinoid and thyroid hormone receptor facilitates cellular recovery from DNA double - strand breaks

  • P. Zacchi, M. Gostissa, +7 authors G. Del Sal
  • Cancer Res .
  • 2006

Similar Papers

Loading similar papers…