Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT

@article{Stanya2008Cdk2AP,
  title={Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT},
  author={Kristopher J. Stanya and Yu Cun Liu and Anthony R. Means and Hung-Ying Kao},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={183},
  pages={49 - 61}
}
Silencing mediator for retinoic acid and thyroid hormone receptor (SMRT) is a transcriptional corepressor that participates in diverse signaling pathways and human diseases. However, regulation of SMRT stability remains largely unexplored. We show that the peptidyl-prolyl isomerase Pin1 interacts with SMRT both in vitro and in mammalian cells. This interaction requires the WW domain of Pin1 and SMRT phosphorylation. Pin1 regulates SMRT protein stability, thereby affecting SMRT-dependent… CONTINUE READING
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