Cdk2 Knockout Mice Are Viable

@article{Berthet2003Cdk2KM,
  title={Cdk2 Knockout Mice Are Viable},
  author={Cyril Berthet and Eiman Aleem and Vincenzo Coppola and Lino Tessarollo and Philipp Kaldis},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={1775-1785}
}
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TLDR
The data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals.
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TLDR
Generating zebrafish cdk1 mutants using CRISPR/Cas9 system suggests that Cdk1 interacts with Cyclin A2 to regulate S phase entry through phosphorylating Top2a, and with cyclin B1 to regulate M phase progression in vivo.
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
TLDR
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Cdk1 is sufficient to drive the mammalian cell cycle
TLDR
It is shown that mouse embryos lacking all interphase Cdks undergo organogenesis and develop to midgestation and that in the absence of interphaseCdks, Cdk1 can execute all the events that are required to drive cell division.
Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6
Cdk2 and Cdk4 cooperatively control the expression of Cdc2
TLDR
It is considered that the balance between proliferation and differentiation is disturbed, which affects especially heart development and leads to embryonic lethality in Cdk2-/-Cdk4-/- mutants.
Cdc2–cyclin E complexes regulate the G1/S phase transition
TLDR
In vivo results provide strong evidence that Cdc2 may compensate the loss of Cdk2 function, indicating a parallel pathway regulated by p27.
Dual Regulation of the Anaphase Promoting Complex in Human Cells by Cyclin A-Cdk2 and Cyclin A-Cdk1 Complexes
TLDR
It is demonstrated that cyclin A-Cdk2 and -Cdk1 complexes display overlapping and partially redundant roles in preparing cells for mitosis, through regulation of the APC, and functional complementation of APC regulation by a compensatory kinase is suggested.
Mammalian cyclin-dependent kinases.
Cdk2 Is Required for p53-Independent G2/M Checkpoint Control
TLDR
It is shown that Cdk2 maintains a balance of S-phase regulatory proteins and thereby coordinates subsequent p53-independent G2/M checkpoint activation, which prevents cells with damaged DNA from initiating mitosis.
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Cyclin-Dependent Kinase-2 Controls Oligodendrocyte Progenitor Cell Cycle Progression and Is Downregulated in Adult Oligodendrocyte Progenitors
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TLDR
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The Oncogenic Activity of Cyclin E Is Not Confined to Cdk2 Activation Alone but Relies on Several Other, Distinct Functions of the Protein*
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G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts
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