Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement

@article{Ramanathan2015Cdk1dependentME,
  title={Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement},
  author={Subramanian P. Ramanathan and J. Helenius and Martin P Stewart and C. J. Cattin and A. Hyman and Daniel J. Muller},
  journal={Nature Cell Biology},
  year={2015},
  volume={17},
  pages={148-159}
}
Actomyosin-dependent mitotic rounding occurs in both cell culture and tissue, where it is involved in cell positioning and epithelial organization. How actomyosin is regulated to mediate mitotic rounding is not well understood. Here we characterize the mechanics of single mitotic cells while imaging actomyosin recruitment to the cell cortex. At mitotic onset, the assembly of a uniform DIAPH1-dependent F-actin cortex coincides with initial rounding. Thereafter, cortical enrichment of F-actin… Expand
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