Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus.

@article{Krasinska2008Cdk1AC,
  title={Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus.},
  author={Liliana Krasinska and Emilie Besnard and Emilie Cot and Christiane Dohet and Marcel M{\'e}chali and Jean-Marc Lemaitre and Daniel G Fisher},
  journal={The EMBO journal},
  year={2008},
  volume={27 5},
  pages={758-69}
}
In this paper, we describe how, in a model embryonic system, cyclin-dependent kinase (Cdk) activity controls the efficiency of DNA replication by determining the frequency of origin activation. Using independent approaches of protein depletion and selective chemical inhibition of a single Cdk, we find that both Cdk1 and Cdk2 are necessary for efficient DNA replication in Xenopus egg extracts. Eliminating Cdk1, Cdk2 or their associated cyclins changes replication origin spacing, mainly by… CONTINUE READING

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