Cdk1-Dependent Regulation of the Mitotic Inhibitor Wee1

  title={Cdk1-Dependent Regulation of the Mitotic Inhibitor Wee1},
  author={Stacy L. Harvey and Alyson Charlet and Wilhelm Haas and Steven P Gygi and Douglas R. Kellogg},
The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby delaying entry into mitosis until appropriate conditions have been met. An understanding of the mechanisms that regulate Wee1 should provide new insight into how cells make the decision to enter mitosis. We report here that Swe1, the budding-yeast homolog of Wee1, is directly regulated by Cdk1. Phosphorylation of Swe1 by Cdk1 activates Swe1 and is required for formation of a stable Swe1-Cdk1 complex that… CONTINUE READING
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