Cdk1, PKCδ and calcineurin-mediated Drp1 pathway contributes to mitochondrial fission-induced cardiomyocyte death.

@article{Zaja2014Cdk1PA,
  title={Cdk1, PKCδ and calcineurin-mediated Drp1 pathway contributes to mitochondrial fission-induced cardiomyocyte death.},
  author={Ivan Zaja and Xiaowen Bai and Yang Liu and Chika Kikuchi and Svjetlana Dosenovic and Yasheng Yan and Scott G Canfield and Zeljko J Bosnjak},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={453 4},
  pages={710-21}
}
Myocardial ischemia-reperfusion (I/R) injury is one of the leading causes of death and disability worldwide. Mitochondrial fission has been shown to be involved in cardiomyocyte death. However, molecular machinery involved in mitochondrial fission during I/R injury has not yet been completely understood. In this study we aimed to investigate molecular mechanisms of controlling activation of dynamin-related protein 1 (Drp1, a key protein in mitochondrial fission) during anoxia-reoxygenation (A/R… CONTINUE READING
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