Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.

@article{Gao2009Cdh1RC,
  title={Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.},
  author={Daming Gao and Hiroyuki Inuzuka and Michael Korenjak and Alan Tseng and Tao Wu and Lixin Wan and Marc Kirschner and Nicholas Dyson and Wenyi Wei},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 14},
  pages={
          3305-16
        }
}
APC/Cdh1 is a major cell cycle regulator and its function has been implicated in DNA damage repair; however, its exact role remains unclear. Using affinity purification coupled with mass spectrometry, we identified Claspin as a novel Cdh1-interacting protein and further demonstrated that Claspin is a novel Cdh1 ubiquitin substrate. As a result, inactivation of Cdh1 leads to activation of the Claspin/Chk1 pathway. Previously, we demonstrated that Rb interacts with Cdh1 to influence its ability… CONTINUE READING
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Control of the SCF ( Skp 2 - Cks 1 ) ubiquitin ligase by the APC / C ( Cdh 1 ) ubiquitin ligase

  • F. Bassermann, D. Frescas, D. Guardavaccaro, L. Busino, A. Peschiaroli, M. Pagano
  • Nature
  • 2008
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