Cdh1 controls the stability of TACC3.

  title={Cdh1 controls the stability of TACC3.},
  author={Jen-Chong Jeng and Ying-Mei Lin and Chiou-Hong Lin and Hsiu-ming Shih},
  journal={Cell cycle},
  volume={8 21},
Transforming acidic coiled-coil protein 3 (TACC3) was reported to be important for regulating mitotic spindle assembly and chromosome segregation. While the protein level of TACC3 was shown to be altered during cell cycle progression, the molecular mechanism in controlling TACC3 level is unclear. Here, we show that TACC3 protein level can be regulated by Cdh1, a well known activator of anaphase-promoting complex/cyclosome. We identified Cdh1 as an interacting partner of TACC3 by a yeast array… CONTINUE READING


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