Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination.

@article{Sasanuma2008Cdc7dependentPO,
  title={Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination.},
  author={Hiroyuki Sasanuma and Kouji Hirota and Tomoyuki Fukuda and Naoko Kakusho and Kazuto Kugou and Yasuo Kawasaki and Takehiko Shibata and Hisao Masai and Kunihiro Ohta},
  journal={Genes & development},
  year={2008},
  volume={22 3},
  pages={
          398-410
        }
}
Meiosis ensures genetic diversification of gametes and sexual reproduction. For successful meiosis, multiple events such as DNA replication, recombination, and chromosome segregation must occur coordinately in a strict regulated order. We investigated the meiotic roles of Cdc7 kinase in the initiation of meiotic recombination, namely, DNA double-strand breaks (DSBs) mediated by Spo11 and other coactivating proteins. Genetic analysis using bob1-1 cdc7Delta reveals that Cdc7 is essential for… CONTINUE READING

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