Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis.

@article{Lo2008Cdc7Dbf4RN,
  title={Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis.},
  author={Hsiao-Chi Lo and Lihong Wan and Adam P. Rosebrock and Bruce Futcher and Nancy M Hollingsworth},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 11},
  pages={
          4956-67
        }
}
In budding yeast, as in other eukaryotes, the Cdc7 protein kinase is important for initiation of DNA synthesis in vegetative cells. In addition, Cdc7 has crucial meiotic functions: it facilitates premeiotic DNA replication, and it is essential for the initiation of recombination. This work uses a chemical genetic approach to demonstrate that Cdc7 kinase has additional roles in meiosis. First, Cdc7 allows expression of NDT80, a meiosis-specific transcriptional activator required for the… CONTINUE READING

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