Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases

@article{Calzada2001Cdc6CW,
  title={Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases},
  author={Arturo Calzada and Mar{\'i}a P Sacrist{\'a}n and Elisa S{\'a}nchez and Avelino Bueno},
  journal={Nature},
  year={2001},
  volume={412},
  pages={355-358}
}
Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinases (CDKs). In the budding yeast, Saccharomyces cerevisiae, inactivation of CDKs during late mitosis involves degradation of B-type cyclins as well as direct inhibition of cyclin–CDK complexes by the CDK-inhibitor protein Sic1 (refs 1,2,3). Several striking similarities exist between Sic1 and Cdc6, a DNA replication factor essential for the formation of pre-replicative complexes at origins of DNA replication… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Regulating DNA replication in eukarya.

Cold Spring Harbor perspectives in biology • 2013
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…