Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells

Abstract

High activation of DNA damage response is implicated in cisplatin (CDDP) resistance which presents as a serious obstacle for bladder cancer treatment. Cdc6 plays an important role in the malignant progression of tumor. Here, we reported that Cdc6 expression is up-regulated in bladder cancer tissues and is positively correlated to high tumor grade. Cdc6… (More)
DOI: 10.18632/oncotarget.9616

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Cite this paper

@inproceedings{Chen2016Cdc6CT, title={Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells}, author={Sansan Chen and Xinglu Chen and Gui'e Xie and Yue He and Daoyu Yan and Dianpeng Zheng and Shi Li and Xinyang Fu and Yeping Li and Xiang Pang and Zhiming Hu and Hongwei Li and Wanlong Tan and Jinlong Li}, booktitle={Oncotarget}, year={2016} }