Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.

@article{Speck2007Cdc6AA,
  title={Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.},
  author={Christian Speck and Bruce W. Stillman},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 16},
  pages={11705-14}
}
DNA replication, as with all macromolecular synthesis steps, is controlled in part at the level of initiation. Although the origin recognition complex (ORC) binds to origins of DNA replication, it does not solely determine their location. To initiate DNA replication ORC requires Cdc6 to target initiation to specific DNA sequences in chromosomes and with Cdt1 loads the ring-shaped mini-chromosome maintenance (MCM) 2-7 DNA helicase component onto DNA. ORC and Cdc6 combine to form a ring-shaped… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

DNA Replication Origin Specificity and ORC and Cdc6 ATPase

  • J. Mendez, B. Stillman
  • APRIL 20,
  • 2007

DNA Replication Origin Specificity and ORC and Cdc6 ATPase 11714 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • J. M. Lemaitre, S. Bocquet, M. andMechali
  • APRIL 20,
  • 2007

Similar Papers

Loading similar papers…