Cdc48/p97 mediates UV-dependent turnover of RNA Pol II.


Cdc48/p97 is an essential ATPase whose role in targeting substrates to the ubiquitin-proteasome system (UPS) remains unclear. Existing models posit that Cdc48 acts upstream of UPS receptors. To address this hypothesis, we examined the association of ubiquitin (Ub) conjugates with 26S proteasomes. Unexpectedly, proteasomes isolated from cdc48 mutants contain… (More)
DOI: 10.1016/j.molcel.2010.12.017


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@article{Verma2011Cdc48p97MU, title={Cdc48/p97 mediates UV-dependent turnover of RNA Pol II.}, author={Rati Verma and Robert S. Oania and Ruihua Fang and Geoffrey T. Smith and Raymond J Deshaies}, journal={Molecular cell}, year={2011}, volume={41 1}, pages={82-92} }