Cdc45-MCM-GINS, a new power player for DNA replication

  title={Cdc45-MCM-GINS, a new power player for DNA replication},
  author={Tom{\'a}s Aparicio and Arkaitz Ibarra and Juan Felipe M{\'e}ndez},
  journal={Cell Division},
  pages={18 - 18}
The identity of the DNA helicase(s) involved in eukaryotic DNA replication is still a matter of debate, but the mini-chromosome maintenance (MCM) proteins are the chief candidate. Six conserved MCM proteins, Mcm2–7, are essential for the initiation and elongation stages of DNA replication, contain ATP binding pockets and can form a hexameric structure resembling that of known prokaryotic and viral helicases. However, biochemical proof of their presumed function has remained elusive. Several… CONTINUE READING

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Excess Mcm2–7 license dormant origins Possible roles of GINS during DNA replication

  • AM Woodward, T Gohler, +5 authors JJ Blow
  • J Cell Biol
  • 2006
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