Cdc42p functions at the docking stage of yeast vacuole membrane fusion.

@article{Mller2001Cdc42pFA,
  title={Cdc42p functions at the docking stage of yeast vacuole membrane fusion.},
  author={Oliver M{\"u}ller and Douglas I. Johnson and Andreas Mayer},
  journal={The EMBO journal},
  year={2001},
  volume={20 20},
  pages={5657-65}
}
Membrane fusion reactions have been considered to be primarily regulated by Rab GTPases. In the model system of homotypic vacuole fusion in the yeast Saccharomyces cerevisiae, we show that Cdc42p, a member of the Rho family of GTPases, has a direct role in membrane fusion. Genetic evidence suggested a relationship between Cdc42p and Vtc1p/Nrf1p, a central part of the vacuolar membrane fusion machinery. Vacuoles from cdc42 temperature-sensitive mutants are deficient for fusion at the restrictive… CONTINUE READING
30 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…