Cdc42 regulates multiple membrane traffic events in fission yeast.

  title={Cdc42 regulates multiple membrane traffic events in fission yeast.},
  author={Miguel Estrav{\'i}s and Sergio Antonio Rinc{\'o}n and Beatriz Maldonado Santos and Pilar P{\'e}rez},
  volume={12 12},
Fission yeast Cdc42 regulates polarized growth and is involved in For3 formin activation and actin cable assembly. We show here that a thermosensitive strain carrying the cdc42L160S allele has membrane traffic defects independent of the actin cable defects. This strain has decreased acid phosphatase (AP) secretion, intracellular accumulation of vesicles and fragmentation of vacuoles. In addition, the exocyst is not localized to the tips of these cells. Overproduction of the scaffold protein… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2015

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