Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation.

@article{Qiu1997Cdc42RA,
  title={Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation.},
  author={R G Qiu and Arie Abo and Frank Mccormick and Marc Symons},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 6},
  pages={3449-58}
}
The Rho family members Cdc42, Rac, and Rho play a central role in the organization of the actin cytoskeleton and regulate transcription. Whereas Rac and Rho have been implicated in transformation by oncogenic Ras, the role of Cdc42 in this process remains unknown. In this study, we found that Rat1 fibroblasts expressing constitutively active V12-Cdc42 were anchorage independent and proliferated in nude mice but failed to show enhanced growth in low serum. Similar to V12-Rac1-expressing Rat1… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 75 extracted citations

Similar Papers

Loading similar papers…