Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos.

@article{BielakZmijewska2008Cdc42PA,
  title={Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos.},
  author={Anna Bielak-Zmijewska and Agnieszka Kolano and Katarzyna Szczepańska and Marek Maleszewski and Ewa Borsuk},
  journal={Developmental biology},
  year={2008},
  volume={322 1},
  pages={21-32}
}
Cdc42 and Rac1 Rho family GTPases, and their interacting protein IQGAP1 are the key regulators of cell polarity. We examined the role of Cdc42 and IQGAP1 in establishing the polarity of mouse oocyte and regulation of meiotic and mitotic divisions. We showed that Cdc42 was localized on the microtubules of meiotic and mitotic spindle and in the cortex of mouse oocytes and cleaving embryos. IQGAP1 was present in the cytoplasm and cortex of growing and fully-grown oocytes. During maturation it… CONTINUE READING

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