Cdc42 is critical for cartilage development during endochondral ossification.

@article{Suzuki2015Cdc42IC,
  title={Cdc42 is critical for cartilage development during endochondral ossification.},
  author={Wataru Suzuki and Atsushi Yamada and Ryo Aizawa and Dai Suzuki and Hidetoshi Kassai and Takeshi Harada and Mutsuko Nakayama and Ryo Nagahama and Koutaro Maki and Shu Takeda and Matsuo Yamamoto and Atsu Aiba and Kazuyoshi Baba and Ryutaro Kamijo},
  journal={Endocrinology},
  year={2015},
  volume={156 1},
  pages={
          314-22
        }
}
Cdc42 is a widely expressed protein that belongs to the family of Rho GTPases and controls a broad variety of signal transduction pathways in a variety of cell types. To investigate the physiological functions of Cdc42 during cartilage development, we generated chondrocyte-specific inactivated Cdc42 mutant mice (Cdc42(fl/fl); Col2-Cre). The gross morphology of mutant neonates showed shorter limbs and body as compared with the control mice (Cdc42(fl/fl)). Skeletal preparations stained with… CONTINUE READING
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