Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity

Abstract

The small Rho GTPase Cdc42, known to interact with Wiskott-Aldrich syndrome (WAS) protein, is an important regulator of actin remodeling. Here, we show that genetic ablation of Cdc42 exclusively in the B cell lineage is sufficient to render mice unable to mount antibody responses. Indeed Cdc42-deficient mice are incapable of forming germinal centers or… (More)
DOI: 10.1084/jem.20141143

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@inproceedings{Burbage2015Cdc42IA, title={Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity}, author={Marianne Burbage and Selina Jessica Keppler and Francesca Gasparrini and Nuria Martinez-Martin and Mauro Gaya and Christoph Feest and Marie-Charlotte Domart and Cord H. Brakebusch and Lucy Collinson and Andreas Bruckbauer and Facundo D. Batista}, booktitle={The Journal of experimental medicine}, year={2015} }