Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease.

@article{Holbert2003Cdc42interactingP4,
  title={Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease.},
  author={S{\'e}bastien Holbert and Alpaslan Dedeoglu and Sandrine Humbert and Fr{\'e}d{\'e}ric Saudou and Robert Ferrante and Christian N{\'e}ri},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 5},
  pages={2712-7}
}
Huntington's disease (HD) is a neurodegenerative disease caused by polyglutamine (polyQ) expansion in the protein huntingtin (htt). Pathogenesis in HD seems to involve the formation of neuronal intranuclear inclusions and the abnormal regulation of transcription and signal transduction. To identify previously uncharacterized htt-interacting proteins in a simple model system, we used a yeast two-hybrid screen with a Caenorhabditis elegans activation domain library. We found a predicted SH3… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…