Cdc42-interacting protein–4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse

@article{Banerjee2007Cdc42interactingPF,
  title={Cdc42-interacting protein–4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse},
  author={Pinaki Prosad Banerjee and Rahul Pandey and Rena Zheng and Megan M. Suhoski and Linda Monaco-Shawver and Jordan S Orange},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={2305 - 2320}
}
An essential function of the immunological synapse (IS) is directed secretion. NK cells are especially adept at this activity, as they direct lytic granules to the synapse for secretion, which enables cytotoxicity and facilitates host defense. This initially requires rearrangement of the actin cytoskeleton and, subsequently, microtubule-dependent trafficking of the lytic granules. As these two steps are sequential, specific linkages between them are likely to serve as critical regulators of… CONTINUE READING
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