Cdc42 in oncogenic transformation, invasion, and tumorigenesis.

@article{Stengel2011Cdc42IO,
  title={Cdc42 in oncogenic transformation, invasion, and tumorigenesis.},
  author={Kristy R. Stengel and Yi cheng Zheng},
  journal={Cellular signalling},
  year={2011},
  volume={23 9},
  pages={1415-23}
}
The Rho family of GTPases represents a class of Ras-related signaling molecules often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP-bound, active state in response to extracellular stimuli such as mitogens and extracellular matrix. In addition, Rho GTPase signaling can be altered in response to cell intrinsic factors such as changes in oncogenic or tumor suppressor signaling. In their active form, these proteins bind to a number of effector molecules… CONTINUE READING
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