Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation.

@article{Ispanovic2008Cdc42AR,
  title={Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation.},
  author={Eric Ispanovic and Damiano Serio and Tara L Haas},
  journal={American journal of physiology. Cell physiology},
  year={2008},
  volume={295 3},
  pages={C600-10}
}
Proteolysis of the basement membrane and interstitial matrix occurs early in the angiogenic process and requires matrix metalloproteinase (MMP) activity. Skeletal muscle microvascular endothelial cells exhibit robust actin stress fibers, low levels of membrane type 1 (MT1)-MMP expression, and minimal MMP-2 activation. Depolymerization of the actin cytoskeleton increases MT1-MMP expression and MMP-2 activation. Rho family GTPases are regulators of actin cytoskeleton dynamics, and their activity… CONTINUE READING

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Caveolae are a novel pathway for C608 Cdc42 AND RhoA REGULATION OF MT1-MMP AND MMP-2 AJP-Cell Physiol

  • BG Galvez, S Matias-Roman, M Yanez-Mo, M Vicente-Manzanares, F Sanchez-Madrid, AG. Arroyo
  • Mol Biol Cell
  • 2008
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