Cdc42 and ARP2/3-independent regulation of filopodia by an integral membrane lipid-phosphatase-related protein.

@article{Sigal2007Cdc42AA,
  title={Cdc42 and ARP2/3-independent regulation of filopodia by an integral membrane lipid-phosphatase-related protein.},
  author={Yury J. Sigal and Omar A. Quintero and Richard E. Cheney and Andrew J. Morris},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 2},
  pages={340-52}
}
Filopodia are dynamic cell surface protrusions that are required for proper cellular development and function. We report that the integral membrane protein lipid-phosphatase-related protein 1 (LPR1) localizes to and promotes the formation of actin-rich, dynamic filopodia, both along the cell periphery and the dorsal cell surface. Regulation of filopodia by LPR1 was not mediated by cdc42 or Rif, and is independent of the Arp2/3 complex. We found that LPR1 can induce filopodia formation in the… CONTINUE READING