Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells

  title={Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells},
  author={Tetsuhisa Otani and Tetsuo Ichii and Shinya Aono and Masatoshi Takeichi},
  journal={The Journal of Cell Biology},
  pages={135 - 146}
Epithelial cells are typically arranged in a honeycomb-like pattern, minimizing their cell-cell contact areas, which suggests that some tension operates for shaping of the cell boundaries. However, the molecular mechanisms that generate such tension remain unknown. We found that Tuba, which is a Cdc42-specific GEF, was concentrated at the apical-most region of cell junctions in simple epithelia via its interaction with ZO-1. RNAi-mediated depletion of Tuba altered the geometrical configuration… CONTINUE READING
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