Cdc42--the centre of polarity.

@article{EtienneManneville2004Cdc42theCO,
  title={Cdc42--the centre of polarity.},
  author={Sandrine Etienne-Manneville},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 8},
  pages={1291-300}
}
All cell types polarize, at least transiently, during division or to generate specialized shapes and functions. This capacity extends from yeast to mammals, and it is now clear that many features of the molecular mechanisms controlling polarization are conserved in all eukaryotic cells. At the centre of the action is Cdc42, a small GTPase of the Rho family. Its activity is precisely controlled both temporally and spatially, and this can be achieved by a wide variety of extracellular cues in… CONTINUE READING
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