Cdc42, but not RhoA, regulates cyclin D1 expression in bovine tracheal myocytes.

@article{Bauerfeld2001Cdc42BN,
  title={Cdc42, but not RhoA, regulates cyclin D1 expression in bovine tracheal myocytes.},
  author={C P Bauerfeld and Marc B Hershenson and Kristen M. Page},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={280 5},
  pages={L974-82}
}
We previously demonstrated that Rac1 increased cyclin D1 promoter activity in an extracellular signal-regulated kinase (ERK)-independent, antioxidant-sensitive manner. Here, we examined the regulation of cyclin D1 expression by Cdc42 and RhoA. Overexpression of active Cdc42, but not of RhoA, induced transcription from the cyclin D1 promoter. Furthermore, dominant negative Cdc42, but not RhoA, attenuated platelet-derived growth factor-mediated activation of the cyclin D1 promoter. Overexpression… CONTINUE READING

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