Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes.

@article{Chymkowitch2012Cdc28KA,
  title={Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes.},
  author={Pierre Chymkowitch and Vegard Eldholm and Susanne Lorenz and Christine Zimmermann and Jessica Margareta Lindvall and Magnar Bj\or{\aa}s and Leonardo Andr{\'e}s Meza-Zepeda and Jorrit M. Enserink},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 26},
  pages={10450-5}
}
The cyclin-dependent kinase Cdc28 is the master regulator of the cell cycle in Saccharomyces cerevisiae. Cdc28 initiates the cell cycle by activating cell-cycle-specific transcription factors that switch on a transcriptional program during late G1 phase. Cdc28 also has a cell-cycle-independent, direct function in regulating basal transcription, which does not require its catalytic activity. However, the exact role of Cdc28 in basal transcription remains poorly understood, and a function for its… CONTINUE READING
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