Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae

@inproceedings{Enserink2009Cdc28Cdk1PA,
  title={Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae},
  author={Jorrit M. Enserink and Hans Hombauer and M Huang and Richard D Kolodner},
  booktitle={The Journal of cell biology},
  year={2009}
}
We studied the function of the cyclin-dependent kinase Cdc28 (Cdk1) in the DNA damage response and maintenance of genome stability using Saccharomyces cerevisiae. Reduced Cdc28 activity sensitizes cells to chronic DNA damage, but Cdc28 is not required for cell viability upon acute exposure to DNA-damaging agents. Cdc28 is also not required for activation of the DNA damage and replication checkpoints. Chemical-genetic analysis reveals that CDC28 functions in an extensive network of pathways… CONTINUE READING